Login



Pull down to log in
×

Warning

JUser: :_load: Unable to load user with ID: 482
JUser: :_load: Unable to load user with ID: 499

News

The groups last publication has been accepted for publication in European Journal of Organic Chemistry (Wiley). This project was entitled as "Erythrosine B catalyzed visible-light photoredox arylation-cyclization of N-alkyl-N-aryl-2-(trifluoromethyl)acrylamides to 3-(trifluoromethyl)indolin-2-one derivatives" and presented by Zsombor Gonda, Ferenc Béke, Orsolya Tischler, Milán Petró, Zoltán Novák and Balázs Tóth. In this work, the novel erythrosine B organic sensitizer dye was utilized as photocatalyst to cyclize the trifluoroacrylamides. You can read this paper already in Accepted Articles section at Wiley. For further reading please, Click Here.

zng pub 58

Our new publication was accepted in Advanced Synthesis & Catalysis (Wiley). This paper is about "Direct ortho-Trifluoroethylation of Aromatic Ureas by Palladium Catalyzed C-H activation: A Missing Piece of Aromatic Substitutions" and released yesterday (15.12.2016).  The authors, Szabolcs Kovács, Balázs L. Tóth, Gábor Borsik, Tamás Bihari, Nóra V. May, András Stirling and Zoltán Novák reported a easily feasible method for trifluoroethylation, which was unprecedented transformation considering the direct alkylation of ureas.

Abstract: Development of direct late-stage installation of alkyl groups into aromatic systems is an important and challenging task of current organic chemistry. In spite of the existing functionalization methods in organic chemistry for the substitution reactions on aromatic systems, the direct alkylation of aromatic ureas is unknown. Herein, as a first example we report a novel palladium catalyzed fluoroalkylation process by C−H activation for the access of ortho trifluoroethylated aromatic ureas. The application of novel, highly active trifluoroethyl(mesityl)iodonium salt enables the efficient introduction of the trifluoroethyl group at 25 °C in 3 hours in high yields (up to 95%) with good functional group tolerance. DFT calculations have revealed a rate determining oxidative alkyl-group transfer preceded by an unexpected C−H activation route on the Pd center during the catalytic cycle, where the deprotonation is assisted by an external triflate anion. For further reading please, Click Here. DOI: 10.1002/adsc.201601136

zng pub 57

Monday, 28 November 2016 15:51

News from October and November

We are happy to announce that, we have new members in our research group!

Dr. Gellért Sipos joined us as a PostDoc. He arrived home from Group of Reto Dorta, The University of Western Australia (UWA).

Milán Petró, Levente Répassy and András Szemes started to work in our laboratories on their BSc. thesis. 

 

Our new publication on C-H activation of aryl urea derivatives has been accepted in Advanced Synthesis and Catalysis (Wiley)! It will be online soon in "Early View" section!

 

Anna Székely passed her PhD final examination. Congratulations!

The Conference of Scientific Students’ Associations (TDK) in Eötvös University was organized on last Saturday (26.11.2016). Péter Elekes, Gergő Sályi, János T. Csenki and Márton Zwillinger attended on this event, and defended their dissertation. Congratulations to them! Considering the summarized points of thesis and the presentation Gergő Sályi received the Árpád Gerecs Price, János T. Csenki got 2nd place and Zwillinger Márton achieved the 1st place! Congratulations! Follow this link for results chart (hungrarian).

The next challenge will come at the XXXIII. National Conference of Scientific Students’ Associations (OTDK) in Faculty Of Materials Science And Engineering, University Of Miskolc, Miskolc, Hungary at 29-31.03.2017.

Saturday, 01 October 2016 13:37

Successful September

The autumn semester started, and several projects were completed successfully. 2 new publications were released in this month.

Our formal group member, Klára Lövei and her co-workers presented a short summary in the topic of flow chemistry. This paper was entitled as "Continuous flow synthesis of heterocyclic scaffolds. Design principles of multistep systems – A review" and published in Chimica Oggi – Chemistry Today (Tekno Scienze). For further reading please, Click Here.

Our second new paper is a study about Lewis acid accelerated palladium catalyzed C-H activation, presented by Orsolya Tischler, Szabolcs Kovács, Gábor Érsek, Péter Králl, János Daru, András Stirling, Zoltán Novák in Journal of Molecular Catalysis A: Chemical (Elsevier). For further reading please, Click Here.

Going beyond to our effective people and their admirable results, it is a pleasure to report, two PhD thesis defence occured on last week.
Zsombor Gonda got Summa Cum Laude on Thursday, and Klári Aradi also finished her study with Summa Cum Laude on Friday. Congratulations!

Our new review was released in Tetrahedron Letters (Elsevier) as a Diggest Letter. This paper focused on a new methodology which started after the beginning of 21st century, and seems to be a diverse, quickly developing branch of organic chemistry. Namely, the idea of photoredox merged transition metal dual catalytic systems. This work collected all of these photoredox-TM catalyzed transformations until 2016 July. The title is "Recent Advances in Dual Transition Metal - Visible Light Photoredox Catalysis" and published by Balázs L. Tóth, Orsolya Tischler, and Zoltán Novák. For further reading please, Click Here.

Read online: Click Here

 zng pub 54

Thursday, 11 August 2016 15:27

Personal Account about Mild C-H Activation

Our first Personal Account was published in The Chemical Record (Wiley) this August. In this comprehensive work we attempted to collect the developments and transformations which avoid the utilization of harsh reaction conditions (high temperature, strong acids and bases and numerous further additives) in the field of palladium catalyzed, ortho-directed C-H activation of aniline derivatives from the first attempts to up-to-date results, including the results of our research laboratory. The title of this review is "Mild Palladium Catalyzed ortho C-H Bond Functionalizations of Aniline Derivatives". For further reading please, Click Here.

zng pub 53

Tuesday, 28 June 2016 13:00

June: Recent events in ZNG

Our new publication has been released in Journal of Organic Chemistry (ACS). This project was entitled as "Understanding and Exploitation of Neighboring Heteroatom Effect for the Mild N‑Arylation of Heterocycles with Diaryliodonium Salts under Aqueous Conditions: A Theoretical and Experimental Mechanistic Study" and presented by Tamás Bihari, Bence Babinszki, Zsombor Gonda, Szabolcs Kovács, Zoltán Novák and András Stirling. Congratulations to them! For further reading please, Click Here.

zng pub 52

 


Changes in group members

• Dr. Szabolcs Kovács (postdoctoral research fellow) left our group and joined to the research team of Prof. Dr. Lukas J. Gooßen at Technische Universität Kaiserslautern.

• Prof. Timothy Peelen and his two BSc. students visited us again. Welcome them! They are going to continue their work here in a joint research project until the end of July. Enjoy your stay in Hungary!

20160616 102316

Janaya Sachs      and      Daniel Corbin

• The BSc. and MSc. final examinations ended. Edina Tóth defended her MSc. thesis and Vivien Pázmándi, Zsófia Bokányi, Zita Makó, Réka Adamik and Mátyás Timári defended their bachelor thesis! Congratulations!

• Ferenc Béke started to work in our group as a PhD. Student.

Saturday, 05 March 2016 08:33

Two Accepted Paper on First of March

We are pleased to announce our two new accepted publications. Interestingly, they were released at the same time on the first day of the spring.

A mechanistic study were presented by Orsolya Tischler, Zsófia Bokányi and Zoltán Novák in Organometallics (ACS). This paper is about "Activation of C–H Activation: The Beneficial Effect of Catalytic Amount of Triaryl Boranes on Palladium-Catalyzed C–H Activation". For further reading please, Click Here.

zng pub 50

 

Parallely, our first review about applications and synthetic pathways of diaryliodonium salts was staged in Synlett (Thieme) by Klára Aradi, Balázs L. Tóth, Gergely L. Tolnai and Zoltán Novák. This account aims to summarize the metal-free direct arylations and copper or palladium catalyzed C-H bond activation reactions which are utilizing these hypervalent iodine reagents. The title of this comprehensive work is "Diaryliodonium Salts in Organic Syntheses: A Useful Compound Class for Novel Arylation Strategies". For further reading please, Click Here.

zng pub 51

Page 2 of 7