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First hit in 2018! Aromatic C-H Alkylation by Sulfonium Salts

C−C bond-forming reactions via aromatic C−H bond activation processes have been studied in this paper. C−H activation based direct alkylations by alkyl group transfer are less explored in this field. However, the introduction of alkyl groups into aromatic systems, especially the ubiquitous methyl group in molecular scaffolds, could have beneficial effects on biological properties. This paper describes "Sulfonium Salts as Alkylating Agents for Palladium-Catalyzed Direct Ortho Alkylation of Anilides and Aromatic Ureas" presented by Dániel Simkó et. al. in Organic Letters (ACS). For further reading, please, Click here.

zng pub 64

Last modified on Monday, 15 January 2018 09:22