Our new theoretical and practical study has been published in Chemical Science (RSC) as an Edge Article. In this investigation we aimed to explain in details the Ortho Effect in Transitional Metal Catalyzed C-H Activation. To provide a comprehensive overview. More than 250 substrates were added to the downloadable Fully Interactive Database. The developed methodology was validated in conceptual experiments, allowing reliable prediction for C-H Activation of custom substrates. For further reading, please, click here.