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Sunday, 23 November 2014 00:00

34. Copper on iron promoted one-pot synthesis of β-aminoenones and 3,5-disubstituted pyrazoles

Copper on iron promoted one-pot synthesis of β-aminoenones and 3,5-disubstituted pyrazoles, Szabolcs Kovács, Zoltán Novák, Tetrahedron 2013, 69, 8987–8993. DOI: 10.1016/j.tet.2013.08.047 |

The reaction of hydroximoyl chlorides with acetylenes in the presence of a copper on iron bimetallic system leads to β-aminoenones via reductive ring opening of isoxazole intermediates. The valuable β-aminoenone building blocks can be isolated or transformed into pyrazoles with the addition of hydrazine in a straightforward one-pot procedure.

zng pub 34