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Saturday, 04 February 2017 13:33

59. Gold-Catalyzed Direct Alkynylation of Azulenes

Gold-Catalyzed Direct Alkynylation of Azulenes, Anna Székely, Áron Péter, Klára Aradi, Gergely L. Tolnai, Zoltán Novák, Org. Lett. 201719, 954-957. DOI: 10.1021/acs.orglett.7b00259 | [Full Text Link] [Supp. Info. Link]

A novel catalytic method for the direct C-H alkynylation of azulenes was developed. The gold catalyzed functionalization of this special carbacycle iwas achieved with hypervalent iodonium reagent TIPS-EBX under mild reaction conditions. With the aid of the developed procedure, several TIPS alkynylated azulene derivatives were synthesized bearing important func-tional groups for further functionalization.

zng pub 59