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Monday, 06 July 2015 13:21

45. Multistep Continuous-Flow Synthesis of Condensed Benzothiazoles

Multistep Continuous-Flow Synthesis of Condensed Benzothiazoles, Klára Lövei, István Greiner, János Éles, Áron Szigetvári, Miklós Dékány, Sándor Lévai, Zoltán Novák, György István Túrós, J. Flow Chem. 2015, 5, 74–81. DOI10.1556/1846.2015.00004 | [Full Text Link[Supp. Info Link]

In medicinal chemistry, the development of synthetic procedures for the access of new heterocyclic systems as potential scaffolds is elementary. Herein, we report our results on the formation of small drug-like heterocycles, utilizing flow chemistry. This approach enables the extension of the reaction parameter window, including high-pressure/high-temperature or hazardous chemistry. In our work, various novel condensed tricyclic benzothiazoles fused with furo- and thieno-rings were synthesized applying a multistep continuous-flow protocol. The process includes two ring closure steps and a nitro group reduction step. Batch and telescoped continuous-flow syntheses were also designed and performed.