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ZNG Research

Our research group was formed in 2007 by Dr. Zoltán Novák Assistant Professor at Eötvös Univeristy in Budapest, Hungary. In the beginning we focused on Palladium catalyzed cross-coupling reactions, however now the scope of our research covers the topic of C-H bond activation, Copper catalyzed reactions, Iron catalyzed reactions, Cross coupling via carbon-heteroatom bond cleavage, Solid supported catalysis, Photoredox catalysis, Domino reactions, Non-atmospherical pressure reactions and Total synthesis of small natural products.

(ELTE-TTK) Eötvös University, Institute of Chemistry, Department of Organic Chemistry
(MTA) Hungarian Academy of Sciences


  • New Paper on Trifluoroethylation of Urea Derivatives

    Our new publication was accepted in Advanced Synthesis & Catalysis (Wiley). This paper is about "Direct ortho-Trifluoroethylation of Aromatic Ureas by Palladium Catalyzed C-H activation: A Missing Piece of Aromatic Substitutions" and released yesterday (15.12.2016).  The authors, Szabolcs Kovács, Balázs L. Tóth, Gábor Borsik, Tamás Bihari, Nóra V. May, András Stirling and Zoltán Novák reported a easily feasible method for trifluoroethylation, which was unprecedented transformation considering the direct alkylation of ureas.

    Abstract: Development of direct late-stage installation of alkyl groups into aromatic systems is an important and challenging task of current organic chemistry. In spite of the existing functionalization methods in organic chemistry for the substitution reactions on aromatic systems, the direct alkylation of aromatic ureas is unknown. Herein, as a first example we report a novel palladium catalyzed fluoroalkylation process by C−H activation for the access of ortho trifluoroethylated aromatic ureas. The application of novel, highly active trifluoroethyl(mesityl)iodonium salt enables the efficient introduction of the trifluoroethyl group at 25 °C in 3 hours in high yields (up to 95%) with good functional group tolerance. DFT calculations have revealed a rate determining oxidative alkyl-group transfer preceded by an unexpected C−H activation route on the Pd center during the catalytic cycle, where the deprotonation is assisted by an external triflate anion. For further reading please, Click Here. DOI: 10.1002/adsc.201601136

    zng pub 57

    Written on Friday, 16 December 2016 15:33
  • News from October and November

    We are happy to announce that, we have new members in our research group!

    Dr. Gellért Sipos joined us as a PostDoc. He arrived home from Group of Reto Dorta, The University of Western Australia (UWA).

    Milán Petró, Levente Répassy and András Szemes started to work in our laboratories on their BSc. thesis. 


    Our new publication on C-H activation of aryl urea derivatives has been accepted in Advanced Synthesis and Catalysis (Wiley)! It will be online soon in "Early View" section!


    Anna Székely passed her PhD final examination. Congratulations!

    The Conference of Scientific Students’ Associations (TDK) in Eötvös University was organized on last Saturday (26.11.2016). Péter Elekes, Gergő Sályi, János T. Csenki and Márton Zwillinger attended on this event, and defended their dissertation. Congratulations to them! Considering the summarized points of thesis and the presentation Gergő Sályi received the Árpád Gerecs Price, János T. Csenki got 2nd place and Zwillinger Márton achieved the 1st place! Congratulations! Follow this link for results chart (hungrarian).

    The next challenge will come at the XXXIII. National Conference of Scientific Students’ Associations (OTDK) in Faculty Of Materials Science And Engineering, University Of Miskolc, Miskolc, Hungary at 29-31.03.2017.

    Written on Monday, 28 November 2016 15:51