ZNGLab - ZNG Research


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ZNG Research

Our research group was formed in 2007 by Dr. Zoltán Novák associate professor at Eötvös Univeristy in Budapest, Hungary. In the beginning we focused on Palladium catalyzed cross-coupling reactions, however now the scope of our research covers the topic of C-H bond activation, Copper catalyzed reactions, Iron catalyzed reactions, Cross coupling via carbon-heteroatom bond cleavage, Solid supported catalysis, Photoredox catalysis, Domino reactions, Non-atmospherical pressure reactions and Total synthesis of small natural products.

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Eötvös Loránd University, Institute of Chemistry, Department of Organic Chemistry

kutatoegyetem(ELTE TTK) Eötvös Loránd Univeristy, Faculty of Science


  • Two New Publications on Pd Catalysis

    This June started with two new papers related to palladium cross-coupling reactions.

    First, we developed palladium-catalyzed functionalization of aryl- and heteroaryl chlorides with sodium tetrakis-(2-chloroethoxy)-borate salt, which is orthogonal to the simple nucleophilic replacement of the chloro function of the ethylene linker. Palladium Catalyzed Chloroethoxylation of Aromatic and Heteroaromatic Chlorides: an Orthogonal Functionalization of Chloroethoxy Linker. Subsequent amine substitution of the alkyl halide affords 2-aminoethoxy arenes. The paper entitled as "Palladium Catalyzed Chloroethoxylation of Aromatic and Heteroaromatic Chlorides: an Orthogonal Functionalization of Chloroethoxy Linker" and published in Organic & Biomolecular Chemistry (RSC).  For further reading, please, Click here.

     zng pub 66

    Second, we disclose a novel catalytic method for the selective deprotection of trimethylsilylacetylenes in Sonogashira reaction. The reagent hexafluorosilicic acid, an inexpensive nontoxic compound, was used to promote the selective desilylation. This paper published by ACS in The Journal of Organic Chemistry as "Catalytic Activation of Trimethylsilylacetylenes: A One-Pot Route to Unsymmetrical Acetylenes and Heterocycles". For further reading, please, Click here.

    zng pub 67

    Written on Monday, 18 June 2018 12:16
  • Synthesis of CF3-Aziridines Published in Angewandte Chemie

    A new route has been discovered to obtain CF3 substituated N-aryl, alkyl and tosylaziridine products. With the utilization of a newly designed, bench stable but highly reactive hypervalent alkenyl iodonium species, the three membered heterocyclic ring can be constructed from simple amines without structural limitation with high efficiency under mild conditions in the absence of transition metal catalysts. The paper entitled as "Design of Trifluoroalkenyliodonium salts for Hypervalency Aided Alkenylation‐Cyclization Strategy: Metal‐free Construction of Aziridine Ring" and published in Angewandte Chemie International Edition (Wiley). For further reading, please, Click here.

    zng pub 65 

    Written on Thursday, 19 April 2018 09:27