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ZNG Research

Our research group was formed in 2007 by Dr. Zoltán Novák associate professor at Eötvös Univeristy in Budapest, Hungary. In the beginning we focused on Palladium catalyzed cross-coupling reactions, however now the scope of our research covers the topic of C-H bond activation, Copper catalyzed reactions, Iron catalyzed reactions, Cross coupling via carbon-heteroatom bond cleavage, Solid supported catalysis, Photoredox catalysis, Domino reactions, Non-atmospherical pressure reactions and Total synthesis of small natural products.

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Eötvös Loránd University, Institute of Chemistry, Department of Organic Chemistry

kutatoegyetem(ELTE TTK) Eötvös Loránd Univeristy, Faculty of Science


  • OPR&D Picked Up

    Our paper entitled "Design of Trifluoroalkenyliodonium salts for Hypervalency Aided Alkenylation‐Cyclization Strategy: Metal‐free Construction of Aziridine Ring" was highlighted by OPR&D! The highlights are selected by a group of industrial chemists as a service to the readership who has a strong interest in practical chemistry that addresses and solves industrial questions.

    The efficient construction of small heterocyclic fluorinated building blocks continues to be a major topic of interest for the synthetic community. Novák and co-workers at Eötvös University in Budapest described a new methodology for the synthesis of trifluoromethylated aziridines that expands for the first time the scope of substrates to nonaromatic amines ( Angew. Chem., Int. Ed. 2018, 57, 6643). For that purpose, the authors designed and synthesized trifluoropropenyl iodonium salts as new C2–CF3 synthons. Under the best conditions, dichloromethane as the solvent with 2 equiv of sodium carbonate as the base, an array of substituted alkylamines as well as (hetero)arylamines were converted into trifluoromethylated aziridines in moderate to high yields. An impressive number of functional groups, including alcohols and unprotected anilines, are well-tolerated. DFT calculations were performed to provide insight into the mechanism of the reaction.

    Wenyi Zhao, Sylvain Guizzetti, James A. Schwindeman, David S. B. Daniels, Carlos A. Guerrero, David Philip Day, John Knight, Org. Process Res. Dev. 2018, 22, 907-917. DOI: 10.1021/acs.oprd.8b00238 | [Full Text Link]


    Written on Tuesday, 28 August 2018 08:03
  • Two New Publications on Pd Catalysis

    This June started with two new papers related to palladium cross-coupling reactions.

    First, we developed palladium-catalyzed functionalization of aryl- and heteroaryl chlorides with sodium tetrakis-(2-chloroethoxy)-borate salt, which is orthogonal to the simple nucleophilic replacement of the chloro function of the ethylene linker. Palladium Catalyzed Chloroethoxylation of Aromatic and Heteroaromatic Chlorides: an Orthogonal Functionalization of Chloroethoxy Linker. Subsequent amine substitution of the alkyl halide affords 2-aminoethoxy arenes. The paper entitled as "Palladium Catalyzed Chloroethoxylation of Aromatic and Heteroaromatic Chlorides: an Orthogonal Functionalization of Chloroethoxy Linker" and published in Organic & Biomolecular Chemistry (RSC).  For further reading, please, Click here.

     zng pub 66

    Second, we disclose a novel catalytic method for the selective deprotection of trimethylsilylacetylenes in Sonogashira reaction. The reagent hexafluorosilicic acid, an inexpensive nontoxic compound, was used to promote the selective desilylation. This paper published by ACS in The Journal of Organic Chemistry as "Catalytic Activation of Trimethylsilylacetylenes: A One-Pot Route to Unsymmetrical Acetylenes and Heterocycles". For further reading, please, Click here.

    zng pub 67

    Written on Monday, 18 June 2018 12:16