Pull down to log in


JUser: :_load: Unable to load user with ID: 482


Sunday, 26 January 2020 18:36

We have two new papers in 2020

The Synthesis, Structural Analysis and Application of Aryl‐Diadamantyl Phosphine ligands in Palladium Catalyzed Cross‐Coupling Reactions have been published in European Journal of Organic Chemistry (Wiley). For further reading, please, click here.

zng pub 76

In a co-operational research project the Microstructure of Nanocrystalline Hydrogen-Storing Mg-Titanate Nanotube Composites have been investigated, and published in Energies (MDPI). For further reading, please, click here.

zng pub 75

Thursday, 29 August 2019 10:50

Shiny Transformations During the Summer

Recently we released two new papers in topic of photoredox catalysis.

Firrst, we were synthesized the highly modular bis(imino)copper(I) complexes and utilized as copper-based photocatalysts in ATRA reactions. The was paper entitled as "Design and application of diimine-based copper(I) complexes in photoredox catalysis" and published in Org. Biomol. Chem. (RSC). For further reading, please, click here.

zng pub 72

Second, we developed a new Ni-Ir dual photocatalytic method for Liebeskind coupling of sulfonium salts with proline to prepare 2‐benzylpyrrolidines. It has been just accepted in Eur. J. Org. Chem. (Wiley). For further reading, please, click here.

zng pub 73


The multifunctional aryl(trifloxyalkenyl)iodonium triflate salts are known for a while, but their preparation has never been easier. In this publication we demonstrated that, theese interesting vinyliodonium salts can be isolated using one-pot method starting from commercially available starting materials. The paper entitled as "Synthesis of Multifunctional Aryl(trifloxyalkenyl)iodonium Triflate Salts" and published in ACS Omega. For further reading, please, Click here.

zng pub 71

We published our new chapter on "Transition Metal‐Catalyzed Reactions with Iodine(III) Reagents" in recent PATAI'S Chemistry of Functional Groups, Hypervalent Halogen Compounds volume. The topic focuses on arylations of aromatic and heteroaromatic systems via C-C bond formations. For further reading, please, Click here.

The most complete resource in functional group chemistry
Patai’s Chemistry of Functional Groups is one of chemistry’s landmark book series in organic chemistry. An indispensible resource for the organic chemist, this is the most comprehensive reference available in functional group chemistry. Founded in 1964 by the late Professor Saul Patai, the aim of Patai’s Chemistry of Functional Groups is to cover all the aspects of the chemistry of an important functional group in each volume, with the emphasis not only on the functional group but on the whole molecule.

The Online Book Series features all the volumes from 1964 to 1995, totalling some 86 classic volumes in print, represented within 83 volumes online (with some volumes merged for the Online Book Series). These are listed below, together with some of the more recent volumes which are available to purchase as part of the electronic major reference work, ePatai. Those books included in the Online Book Series are volumes from 1964 to 1995 (those shown without dates are excluded). All volumes from 1995 onwards (currently 26 volumes) are available as an electronic major reference work, for more information on ePatai, click here.

Each volume contains detailed information on the chemistry of the functional group with the following topics featured in each volume.

General, theoretical and computational aspects of the functional group, for example, quantum chemical treatment, structural and conformational chemistry and thermochemistry.Characterisation and characteristics of the functional groups with chapters covering both qualitative and quantitative methods of determination such as UV, IR, NMR, ESR, PES, RD, CD and mass spectrometry. It will also cover the basicity, acidity or the complex forming ability of the group.

The formation of the functional group and the reactions, transformations and rearrangements which the functional group can undergo, also including synthesis and reaction mechanisms as diverse as photochemistry, radiation chemistry, biochemical formation or classic synthesis and catalysis.

The biological aspects in both biochemistry and molecular biology as well as its application in medicinal chemistry, drug development and drug discovery.

Data and reviews on the important industrial applications in fields such as polymers, materials and nano-materials.Patai’s Chemistry of Functional Groups is much more than just data. It provides detailed insights, review sand overviews on each functional group featured. This depth of content is the strength of the series as well as its broad coverage of techniques, methods, theory and applications.

To download a brochure or find out further information about both the electronic major reference work or take a tour, go to wiley.com/go/patai

Wednesday, 19 December 2018 11:06

Hot Topic: C-C Coupling

Our review entitled "Synthesis of aryl‐ and heteroaryl‐trifluoroethyl ethers: aims, challenges and new methodologies" was highlighted by Wiley Hot Topic: C-C Coupling.

The development of metal-catalyzed cross-coupling reactions over the past 30 years has revolutionized the way, carbon-carbon bonds between sp and sp2 carbon atoms are formed. These methods have profoundly changed the protocols for the construction of natural products, building blocks for supramolecular chemistry and self-assembly, organic materials and polymers, and lead compounds in medicinal chemistry from simpler entities. The 2010 Nobel prize in chemistry for E. Negishi, R. Heck, and A. Suzuki underlines the importance of direct bond formation betweeen carbon atoms. Read articles.


Tuesday, 28 August 2018 08:03

OPR&D Picked Up

Our paper entitled "Design of Trifluoroalkenyliodonium salts for Hypervalency Aided Alkenylation‐Cyclization Strategy: Metal‐free Construction of Aziridine Ring" was highlighted by OPR&D! The highlights are selected by a group of industrial chemists as a service to the readership who has a strong interest in practical chemistry that addresses and solves industrial questions.

The efficient construction of small heterocyclic fluorinated building blocks continues to be a major topic of interest for the synthetic community. Novák and co-workers at Eötvös University in Budapest described a new methodology for the synthesis of trifluoromethylated aziridines that expands for the first time the scope of substrates to nonaromatic amines ( Angew. Chem., Int. Ed. 2018, 57, 6643). For that purpose, the authors designed and synthesized trifluoropropenyl iodonium salts as new C2–CF3 synthons. Under the best conditions, dichloromethane as the solvent with 2 equiv of sodium carbonate as the base, an array of substituted alkylamines as well as (hetero)arylamines were converted into trifluoromethylated aziridines in moderate to high yields. An impressive number of functional groups, including alcohols and unprotected anilines, are well-tolerated. DFT calculations were performed to provide insight into the mechanism of the reaction.

Wenyi Zhao, Sylvain Guizzetti, James A. Schwindeman, David S. B. Daniels, Carlos A. Guerrero, David Philip Day, John Knight, Org. Process Res. Dev. 2018, 22, 907-917. DOI: 10.1021/acs.oprd.8b00238 | [Full Text Link]


Monday, 18 June 2018 12:16

Two New Publications on Pd Catalysis

This June started with two new papers related to palladium cross-coupling reactions.

First, we developed palladium-catalyzed functionalization of aryl- and heteroaryl chlorides with sodium tetrakis-(2-chloroethoxy)-borate salt, which is orthogonal to the simple nucleophilic replacement of the chloro function of the ethylene linker. Palladium Catalyzed Chloroethoxylation of Aromatic and Heteroaromatic Chlorides: an Orthogonal Functionalization of Chloroethoxy Linker. Subsequent amine substitution of the alkyl halide affords 2-aminoethoxy arenes. The paper entitled as "Palladium Catalyzed Chloroethoxylation of Aromatic and Heteroaromatic Chlorides: an Orthogonal Functionalization of Chloroethoxy Linker" and published in Organic & Biomolecular Chemistry (RSC).  For further reading, please, Click here.

 zng pub 66

Second, we disclose a novel catalytic method for the selective deprotection of trimethylsilylacetylenes in Sonogashira reaction. The reagent hexafluorosilicic acid, an inexpensive nontoxic compound, was used to promote the selective desilylation. This paper published by ACS in The Journal of Organic Chemistry as "Catalytic Activation of Trimethylsilylacetylenes: A One-Pot Route to Unsymmetrical Acetylenes and Heterocycles". For further reading, please, Click here.

zng pub 67

A new route has been discovered to obtain CF3 substituated N-aryl, alkyl and tosylaziridine products. With the utilization of a newly designed, bench stable but highly reactive hypervalent alkenyl iodonium species, the three membered heterocyclic ring can be constructed from simple amines without structural limitation with high efficiency under mild conditions in the absence of transition metal catalysts. The paper entitled as "Design of Trifluoroalkenyliodonium salts for Hypervalency Aided Alkenylation‐Cyclization Strategy: Metal‐free Construction of Aziridine Ring" and published in Angewandte Chemie International Edition (Wiley). For further reading, please, Click here.

zng pub 65 

Page 1 of 7