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Sunday, 10 September 2017 14:57

September starts with two new publications

We are pleased to share our new papers.

Aradi K. and her co-workers presented a mild N-arylation of nitroenamine derivatives utilizing diaryliodonium triflates and copper(I) chloride as a catalyst. For further reading, please, click here.

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Pethő B. and his co-workers developed a synthetic method for 2,2,2-trifluoroethoxylation of aromatic and heteroaromatic chlorides utilizing borate salt. Under palladium catalyzed reaction conditions an additional analog of Sildenafil was synthetized also. The paper was published in Chemistry - A European Journal (Wiley).For further reading, please, click here.

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Our group was presented a new syhtetic method for the desilylation of silylacetylenes via aquaous solution of hexafluorosilicic acid. The applicability of the novel, cheap and environmentally friendly reagent was demonstrated in the sequential coupling of aryl halides and ethynyltrimethylsilane to afford internal acetylenes, benzofurans, and triazoles in one-pot reactions. This paper has been published in Synthesis (Thieme) and entitled as "Hexafluorosilicic Acid as a Novel Reagent for the Desilylation of Silylacetylenes: Application in Sequential Sonogashira Coupling and Click Reaction". For further reading, please, click here.

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 The applicability of the aqueous solution of the hexafluorosilicic acid was demonstrated in the sequential coupling of aryl halides and ethynyltrimethylsilane to afford internal acetylenes, benzofurans, and triazoles in one-pot
Saturday, 04 February 2017 14:12

Synthesis of Azulenes in Organic Letters

Our new paper has been published in topic of azulene chemistry, in Organic Letters (ACS)! This paper entitled as "Gold-Catalyzed Direct Alkynylation of Azulenes" and contains 18 examples of novel TIPS-acetilene-azulenes. For further reading please, Click Here.

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The groups last publication has been accepted for publication in European Journal of Organic Chemistry (Wiley). This project was entitled as "Erythrosine B catalyzed visible-light photoredox arylation-cyclization of N-alkyl-N-aryl-2-(trifluoromethyl)acrylamides to 3-(trifluoromethyl)indolin-2-one derivatives" and presented by Zsombor Gonda, Ferenc Béke, Orsolya Tischler, Milán Petró, Zoltán Novák and Balázs Tóth. In this work, the novel erythrosine B organic sensitizer dye was utilized as photocatalyst to cyclize the trifluoroacrylamides. You can read this paper already in Accepted Articles section at Wiley. For further reading please, Click Here.

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Our new publication was accepted in Advanced Synthesis & Catalysis (Wiley). This paper is about "Direct ortho-Trifluoroethylation of Aromatic Ureas by Palladium Catalyzed C-H activation: A Missing Piece of Aromatic Substitutions" and released yesterday (15.12.2016).  The authors, Szabolcs Kovács, Balázs L. Tóth, Gábor Borsik, Tamás Bihari, Nóra V. May, András Stirling and Zoltán Novák reported a easily feasible method for trifluoroethylation, which was unprecedented transformation considering the direct alkylation of ureas.

Abstract: Development of direct late-stage installation of alkyl groups into aromatic systems is an important and challenging task of current organic chemistry. In spite of the existing functionalization methods in organic chemistry for the substitution reactions on aromatic systems, the direct alkylation of aromatic ureas is unknown. Herein, as a first example we report a novel palladium catalyzed fluoroalkylation process by C−H activation for the access of ortho trifluoroethylated aromatic ureas. The application of novel, highly active trifluoroethyl(mesityl)iodonium salt enables the efficient introduction of the trifluoroethyl group at 25 °C in 3 hours in high yields (up to 95%) with good functional group tolerance. DFT calculations have revealed a rate determining oxidative alkyl-group transfer preceded by an unexpected C−H activation route on the Pd center during the catalytic cycle, where the deprotonation is assisted by an external triflate anion. For further reading please, Click Here. DOI: 10.1002/adsc.201601136

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Monday, 28 November 2016 15:51

News from October and November

We are happy to announce that, we have new members in our research group!

Dr. Gellért Sipos joined us as a PostDoc. He arrived home from Group of Reto Dorta, The University of Western Australia (UWA).

Milán Petró, Levente Répassy and András Szemes started to work in our laboratories on their BSc. thesis. 

 

Our new publication on C-H activation of aryl urea derivatives has been accepted in Advanced Synthesis and Catalysis (Wiley)! It will be online soon in "Early View" section!

 

Anna Székely passed her PhD final examination. Congratulations!

The Conference of Scientific Students’ Associations (TDK) in Eötvös University was organized on last Saturday (26.11.2016). Péter Elekes, Gergő Sályi, János T. Csenki and Márton Zwillinger attended on this event, and defended their dissertation. Congratulations to them! Considering the summarized points of thesis and the presentation Gergő Sályi received the Árpád Gerecs Price, János T. Csenki got 2nd place and Zwillinger Márton achieved the 1st place! Congratulations! Follow this link for results chart (hungrarian).

The next challenge will come at the XXXIII. National Conference of Scientific Students’ Associations (OTDK) in Faculty Of Materials Science And Engineering, University Of Miskolc, Miskolc, Hungary at 29-31.03.2017.

Saturday, 01 October 2016 13:37

Successful September

The autumn semester started, and several projects were completed successfully. 2 new publications were released in this month.

Our formal group member, Klára Lövei and her co-workers presented a short summary in the topic of flow chemistry. This paper was entitled as "Continuous flow synthesis of heterocyclic scaffolds. Design principles of multistep systems – A review" and published in Chimica Oggi – Chemistry Today (Tekno Scienze). For further reading please, Click Here.

Our second new paper is a study about Lewis acid accelerated palladium catalyzed C-H activation, presented by Orsolya Tischler, Szabolcs Kovács, Gábor Érsek, Péter Králl, János Daru, András Stirling, Zoltán Novák in Journal of Molecular Catalysis A: Chemical (Elsevier). For further reading please, Click Here.

Going beyond to our effective people and their admirable results, it is a pleasure to report, two PhD thesis defence occured on last week.
Zsombor Gonda got Summa Cum Laude on Thursday, and Klári Aradi also finished her study with Summa Cum Laude on Friday. Congratulations!

Our new review was released in Tetrahedron Letters (Elsevier) as a Diggest Letter. This paper focused on a new methodology which started after the beginning of 21st century, and seems to be a diverse, quickly developing branch of organic chemistry. Namely, the idea of photoredox merged transition metal dual catalytic systems. This work collected all of these photoredox-TM catalyzed transformations until 2016 July. The title is "Recent Advances in Dual Transition Metal - Visible Light Photoredox Catalysis" and published by Balázs L. Tóth, Orsolya Tischler, and Zoltán Novák. For further reading please, Click Here.

Read online: Click Here

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