Login



Pull down to log in

2019

Development of Ni‐Ir dual photocatalytic Liebeskind coupling of sulfonium salts for the synthesis of 2‐benzylpyrrolidines, Bálint Varga, Zsombor Gonda, Balázs L. Tóth, András Kotschy, Zoltán Novák, Eur. J. Org. Chem. 2019. ASAP DOI: 10.1002/ejoc.201900957 | [Full Text Link] [Supp. Info. Link]

A new method has been developed for the synthesis of 2‐benzylpyrrolidines utilizing cross‐coupling and photoredox catalysis. Using a well‐established dual Ni‐Ir system, we were able to successfully couple benzylsulfonium salts with a proline utilizing radical forming through CO2 extrusion. This enabled the simple one step synthesis of 2‐benzylpyrrolidines from stable inexpensive starting materials.

zng pub 73

Design and application of diimine-based copper(I) complexes in photoredox catalysis, Tamás Földesi, Réka Adamik, Gellert Sipos, Bálint Nagy, Balázs L. Tóth, Attila Benyei, Krisztina Szekeres, Győző Láng, Attila Demeter, Timothy Peelen, Zoltán Novák, Org. Biomol. Chem. 201917, 8343-8347. DOI: 10.1039/C9OB01331H | [Full Text Link] [Supp. Info. Link, CIF]

Structurally different bis(imino)copper(I) complexes were prepared in a highly modular manner and utilized as copper-based photocatalysts in ATRA reactions of styrenes and alkyl halides. The new photocatalysts showed good catalytic activity and ensured efficient chemical transformations.

zng pub 72

Front cover of the issue: Org. Biomol. Chem.2019,17, 8263-8264. DOI:10.1039/C9OB90149C | [Full Text Link]

zng pub 72 2

 

Synthesis of Multifunctional Aryl(trifloxyalkenyl)iodonium Triflate Salts, Balázs L. Tóth, Ferenc Béke, Orsolya Egyed, Attila Bényei, András Stirling, Zoltán Novák, ACS Omega 2019, 45, 9188-9197. DOI: 10.1021/acsomega.9b00728 | [Full Text Link] [Supp. Info. Link, CIF]

A convenient procedure for the synthesis of aryl(trifloxyalkenyl)iodonium triflate salts from commercially available (diacetoxyiodo)benzene, trimethylsilyl trifluoromethanesulfonate, and acetylenes under mild conditions was developed. The obtained multifunctional hypervalent vinyliodonium salts equipped with electrophilic and nucleophilic functions could serve as novel C2 synthons for organic transformations. The structure of the iodonium salts was identified by multidimensional NMR spectroscopy and X-ray crystallography.

zng pub 71

Synthesis of aryl‐ and heteroaryl‐trifluoroethyl ethers: aims, challenges and new methodologies, Bálint Pethő, Zoltán Novák, Asian J. Org. Chem. 2019, 568-575. DOI: 10.1002/ajoc.201800414 | [Full Text Link]

Focus Review: Fluorinated substances have outstanding importance in most fields of the chemical industry, from agrochemicals and material science to pharmaceutical research. Although aryl‐ and heteroaryl‐trifluoroethyl ethers have widespread applications, predominantly as drug molecules, their preparation was limited to classical synthetic methodologies until the last decade. The transition metal catalyzed cross coupling reactions offered novel synthetic approaches for the facile access of trifluoroethoxylated aromatic compounds. The aim of this review is to give a good overview on recent advances in the synthesis of aryl‐trifluoroethyl ethers from a practical point of view for synthetic organic chemists working in the field of pharmaceutical industry and academia.

zng pub 69