Continuous flow synthesis of heterocyclic scaffolds. Design principles of multistep systems – A review, Klára Lövei, Péter Bana, Róbert Örkényi, György I. Túrós, János Éles, Zoltán Novák, Ferenc Faigl, Chim. Oggi Chem. Today, 2016, 34, 18-21. Link

KEYWORDS: Continuous flow synthesis, condensed heterocycles, scaffold, multistep flow synthesis, telescoping.

ABSTRACT: The synthesis of novel heterocycles is an essential task in small-molecule drug discovery. Continuous flow processing opens the way for a new paradigm in laboratory-scale synthesis as well as pharmaceutical manufacturing. Based on our experiences with the multistep synthesis of condensed benzothiazoles, we gathered some of the key design features in light of literature examples.