Development of Ni‐Ir dual photocatalytic Liebeskind coupling of sulfonium salts for the synthesis of 2‐benzylpyrrolidines, Bálint Varga, Zsombor Gonda, Balázs L. Tóth, András Kotschy, Zoltán Novák, Eur. J. Org. Chem. 2020. 10, 1466-1471. DOI: 10.1002/ejoc.201900957 | [Full Text Link] [Supp. Info. Link]
A new method has been developed for the synthesis of 2‐benzylpyrrolidines utilizing cross‐coupling and photoredox catalysis. Using a well‐established dual Ni‐Ir system, we were able to successfully couple benzylsulfonium salts with a proline utilizing radical forming through CO2 extrusion. This enabled the simple one step synthesis of 2‐benzylpyrrolidines from stable inexpensive starting materials.
