Synthesis and Photochemical Application of Hydrofluoroolefin (HFO) Based Fluoroalkyl Building Block, Bálint Varga, Balázs L. Tóth, Ferenc Béke, János T. Csenki, András Kotschy, Zoltán Novák, Org. Lett. 2021, 23, 4925–4929. DOI: 10.1021/acs.orglett.1c01709 | [Full Text Link] [Supp. Info. Link]

A novel fluoroalkyl iodide was synthesized on multigram scale from refrigerant gas HFO-1234yf as cheap industrial starting material in a simple, solvent-free, and easily scalable process. We demonstrated its applicability in a metal-free photocatalytic ATRA reaction to synthesize valuable fluoroalkylated vinyl iodides and proved the straightforward transformability of the products in cross-coupling chemistry to obtain conjugated systems.