The Potential of Micellar Media in the Synthesis of DNA-Encoded Libraries, Réka Adamik, Balázs Buchholcz, Ferenc Darvas, Gellért Sipos, Zoltán Novák, Chem. Eur. J. 2022, 28, e202103967. DOI: 10.1002/chem.202103967 | [Full Text Link]

DNA-encoded libraries (DELs) have become a widely used technology in drug discovery. The use of micelle-forming surfactants provides new possibilities for synthetic organic chemistry and could be a promising technique for DNA-compatible chemistry as well. This review provides a summary of existing examples of micellar DEL approaches, together with a selection of micellar organic transformations fundamentally suitable for DEL synthesis.

Highlighted as a Frontispiece. Chem. Eur. J. 2022, 28, e202282062. DOI: 10.1002/chem.202282062 | [Full Text Link]