Sequential and domino Sonogashira coupling: Efficient tools for the synthesis of diarylalkynes, András Nagy, Zoltán Novák, András Kotschy, J. Organomet. Chem. 2005, 690, 4453-4461. DOI: 10.1016/j.jorganchem.2004.12.036 |

The Sonogashira coupling reaction of aryl halides with a masked acetylene, leading to the formation of diarylethynes is reviewed. The process is either run in a sequential coupling–deprotection–coupling manner, or sometimes it is carried out in one-pot, a reaction we coined domino coupling. The procedures were also extended to the synthesis of compound libraries.