Utilization of Copper-Catalyzed Carboarylation–Ring Closure for the Synthesis of New Oxazoline Derivatives, Ádám Sinai, Dóra Vangel, Tamás Gáti, Petra Bombicz, Zoltán Novák, Org. Lett. 2015, 17, 4136-4139. DOI: 10.1021/acs.orglett.5b01860 | [Full Text Link] [Supp. Info. Link, CIF]

A copper-catalyzed carboarylation–ring-closure strategy was used for the modular synthesis of oxazolines via the reaction of 1-aryl- and 1-alkylpropargylamides and diaryliodonium salts. The novel approach enables the efficient, modular synthesis of oxazoline derivatives bearing fully substituted exo double bonds.