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News

Tuesday, 09 February 2016 07:21

Changes in the members of the group

We have some :

Newcomers: Ágnes Tóth (BSc) and Eszter Szombati (BSc) decided to work on their BSc in our research group.

Old-new comer: Dóri Vangel (MSc) returned to us.

PhD-migration: 

Klára Aradi started to work at Szent István University, Faculty of Veterinary Science besides her PhD studies in coorperation with Vincze Zoltán.

Balázs Tóth spends this term (February - July) in the research group of Burkhard König in the University of Regensburg, Germany.

Bálint Pethő has successfully applied for the internship of l'Oréal, he will spend this term (March - August) in Paris, France.

Fortunately, we can present here our two new papers which were published already in 2016 January. These examples are all about the exploration of the hypervalent iodonium salts' reactivity in transition metal catalyzed transformations.

The first paper is about the"Modular Copper-Catalyzed Synthesis of Chromeno[4,3-b]quinolines with the Utilization of Diaryliodonium Salts" and released in Journal of Organic Chemistry (ACS) by Klára Aradi, Petra Bombicz, Zoltán Novák. For further reading, please Click here.

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Further, It is a big pleasure to introduce our first Angewandte Chemie International Edition (Wiley) publication, which describes a new procedure for trifluoroethylation of N-aryl amides via ortho C-H bond Activation. The power of this synthetic method has been demonstrated by preparation of 43 new trifluoroethylated molecules. The paper is entitled as "Mild and Efficient Palladium-Catalyzed Direct Trifluoroethylation of Aromatic Systems by C-H Activation" and presented by Balázs L. Tóth, Szabolcs Kovács, Gergő Sályi, Zoltán Novák. To our great delight this work has been highlited in this journal as a Frontispiece and a scientific graphics made, what you can see below. For further reading, please Click here.

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Monday, 20 July 2015 10:54

Conferences during the summer

We have important  results that we can report. In every second year, the Scientific Symposium for students is organized in Hungary. From our group Edina Tóth (MSc), Dániel Lasányi (BSc) and Márton Zwillinger (BSc) participated in the symposium. Dani reached 3rd place and Marci got 1st prize in the field of organic chemistry. Congratulations!

There were several conferences as well during the summer. In the end of May (27-29th), Heterocyclic Workgroup, Hungarian Academy of Science took place in Balatonszemes, where 4 PhD and 1 BSc students presented their work: Klára Aradi, Orsolya Tischler, Balázs Tóth, Anna Székely and Dániel Lasányi.
Two weeks later (14-17th June) Blue Danube Symposium on Heterocyclic Compounds took place at Lake Balaton again, this time in Balatonalmádi. We presented 4 posters: Klára Aradi, Bálint Pethő, Orsolya Tischler, Ádám Sinai and a lecture: Anna Székely.
At the same time an International Summer School on Organic Synthesis was organized between 14-18th June in Milano, Italy. Dániel Simkó and Balázs Tóth represented our group with posters.
Next month Organometallic Chemistry Directed Towards Organic Synthesis took place near Barcelona, Spain between 28th June and 2nd July, where our group participated with 4 posters from Klára Aradi, Zoltán Novák, Orsolya Tischler and Balázs Tóth.
Later this month (11-15th July) we have attended European Symposium on Organic Chemistry in Lisbon, Portugal with 5 posters: Szabolcs Kovács, Zoltán Novák, Orsolya Tischler, Balázs Tóth and Anna Székely.

We have important changes regarding the members of the group. Gergely Tolnai has successfully applied for a Post doc position in the group of prof. Berit Olofsson. In April he moved to Sweden with his family.

At the same time, we welcomed two new members: Réka Adamik and Mátyás Timári, both working on their BSc studies.Also, we are glad to announce that we have a new-old visiting professor from the USA, prof. Timothy Peelen. He has already been here in 2013 for 6 months. Now, he brought 2 students with him to work with us for 2 months: Cody Lloyd and Darnell Pierre.

Cody Darnell

 

Efficient Direct 2,2,2-Trifluoroethylation of Indoles via C-H Functionalization, Gergely László Tolnai, Anna Székely, Zita Makó, Tamás Gáti, János Daru, Tamás Bihari, Andras Stirling and Zoltán Novák, Chem. Commun. 2015, DOI: 10.1039/C5CC00519A

A novel highly C3 selective metal free trifluoroethylation of indoles using 2,2,2-trifuoroethyl(mesityl)-iodonium triflate was developed. The methodology enables the introduction of a trifluoroethyl group in a fast and efficient reaction under mild conditions with high functional group tolerance. Beyond the synthetic developments, quantum chemical calculations provide a deeper understanding of the transformation.

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Copper-Catalyzed Oxidative Ring Closure of ortho-Cyanoanilides with Hypervalent Iodonium Salts: Arylation–Ring Closure Approach to Iminobenzoxazines, Klára Aradi, Zoltán Novák, Adv. Synt. Catal. 2015357, 371-376. DOI: 10.1002/adsc.201400763

A novel, highly modular synthetic methodology with high functional group tolerance was developed for the construction of iminobenzoxazine derivatives from ortho-cyanoanilides and diaryliodonium triflates via an oxidative arylation–cyclization path. The reaction is supposed to involve the formation of highly active aryl-copper(III) species. In this novel transformation, copper(II) triflate was used as catalyst in 1,2-dichloroethane or ethyl acetate and the reaction takes place at 75 °C in 2–16 h.

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Synthesis and Transformations of Oxygen Heterocycles, Zoltán Novák, András Kotschy. Topics in Heterocyclic Chemistry 2014. DOI: 10.1007/7081_2014_136

The recent developments in the transition metal-catalyzed synthesis and transformations of such oxygen-containing heteroaromatic systems are reviewed, where the oxygen is part of a five-membered ring.

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Tuesday, 02 December 2014 13:46

Fruzsi received PhD. degree

Fruzsi successfully defended her PhD thesis. Congratulations!

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