Our latest results in 2,2,2-Trifluoroethylation of Indoles were published in Chemical Communications!
Efficient Direct 2,2,2-Trifluoroethylation of Indoles via C-H Functionalization, Gergely László Tolnai, Anna Székely, Zita Makó, Tamás Gáti, János Daru, Tamás Bihari, Andras Stirling and Zoltán Novák, Chem. Commun. 2015, DOI: 10.1039/C5CC00519A
A novel highly C3 selective metal free trifluoroethylation of indoles using 2,2,2-trifuoroethyl(mesityl)-iodonium triflate was developed. The methodology enables the introduction of a trifluoroethyl group in a fast and efficient reaction under mild conditions with high functional group tolerance. Beyond the synthetic developments, quantum chemical calculations provide a deeper understanding of the transformation.
Our new paper has been published in Advaced Synthesis & Catalysis!
Copper-Catalyzed Oxidative Ring Closure of ortho-Cyanoanilides with Hypervalent Iodonium Salts: Arylation–Ring Closure Approach to Iminobenzoxazines, Klára Aradi, Zoltán Novák, Adv. Synt. Catal. 2015, 357, 371-376. DOI: 10.1002/adsc.201400763
A novel, highly modular synthetic methodology with high functional group tolerance was developed for the construction of iminobenzoxazine derivatives from ortho-cyanoanilides and diaryliodonium triflates via an oxidative arylation–cyclization path. The reaction is supposed to involve the formation of highly active aryl-copper(III) species. In this novel transformation, copper(II) triflate was used as catalyst in 1,2-dichloroethane or ethyl acetate and the reaction takes place at 75 °C in 2–16 h.
A book chapter was published in Topics in Heterocyclic Chemistry
Synthesis and Transformations of Oxygen Heterocycles, Zoltán Novák, András Kotschy. Topics in Heterocyclic Chemistry 2014. DOI: 10.1007/7081_2014_136
The recent developments in the transition metal-catalyzed synthesis and transformations of such oxygen-containing heteroaromatic systems are reviewed, where the oxygen is part of a five-membered ring.
Fruzsi received PhD. degree
Fruzsi successfully defended her PhD thesis. Congratulations!
ELTE Conference of Scientific Students’ Associations results
The Conference of Scientific Students’ Associations (TDK) was organized this year too at ELTE. Considering the points of thesis and the presentation Márton Zwillinger performed in the first place and Dániel Lasányi received the third prize. Congratulations to them!
The next challenge will come at the National Conference of Scientific Students’ Associations (OTDK) in Veszprém (2015 april 9-11).
